Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination

A computer-implemented method of facilitating risk assessment of an ischemic lesion based at least in part on non-invasive medical image analysis of myocardium subtended by the ischemic lesion, the method comprising:

• accessing, by a computer system, a medical image of a subject, wherein the medical image of the subject is obtained non-invasively;
• analyzing, by the computer system, the medical image of the subject to map a plurality of vessels, the plurality of vessels comprising one or more regions of plaque;
• identifying, by the computer system, the one or more regions of plaque within the plurality of vessels;
• analyzing, by the computer system, the one or more regions of plaque to generate a plurality of plaque parameters, the plurality of plaque parameters comprising density and volume of the one or more regions of plaque;
• determining, by the computer system, an ischemic lesion in the plurality of vessels based at least in part on the plurality of plaque parameters;
• determining, by the computer system, myocardium subtended by the ischemic lesion and myocardium not subtended by the ischemic lesion based at least in part on mapping of the plurality of vessels;
• and
• generating, by the computer system, a graphical visualization of the myocardium subtended by the ischemic lesion and the myocardium not subtended by the ischemic lesion, wherein the graphical visualization of the myocardium subtended by the ischemic lesion compared to the myocardium not subtended by the ischemic lesion is configured to be utilized to determine risk of the ischemic lesion to the subject, wherein a higher amount of myocardium subtended by the ischemic lesion is indicative of higher risk compared to a lower amount of myocardium subtended by the ischemic lesion,
• wherein the computer system comprises a computer processor and an electronic storage medium.