Computational in silico model for cornea barrier

Abstract

The method involves computationally modeling a cornea by simulating physical cornea models with computational in silico models. The simulated data is compared with actual data from the physical models, and the simulation is iterated until a match is achieved. The method may also include calibrating diffusion parameters for testing substances, and configuring the models for analyzing instances of fluid-induced shear and substance transport. The simulated data may be used to obtain corneal pharmacokinetic models, and the method may be used to obtain predictions for time-dependent concentrations of molecules in the eye or systemic circulation. The computational models may consider instances of convective-diffusive transport and carrier-mediated transport in calculations and determinations of transport characteristics and values of different testing substances.

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