Crystalline forms, pharmaceutical compositions and methods of use thereof
AssigneeTango Therapeutics, Inc.
InventorsKimberly Jane Briggs, Kevin M. Cottrell, Sapna Makhija Garad, Magnus Ronn
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Abstract
Crystalline forms and pharmaceutical compositions of a PRMT5 inhibitor of formula (I), methods of making the pharmaceutical compositions of the PRMT5 inhibitor of formula (I) and methods of using the PRMT5 inhibitor of formula (I) or crystalline solid forms and pharmaceutically acceptable compositions thereof.
Claims24
A crystalline form of N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide (a compound of formula (I))
- wherein the X-ray powder diffraction (XRPD) pattern of the crystalline form comprises one or more peaks at 2θ angles selected from 4.4±0.2, 9.6±0.2, 16.8±0.2, 18.6±0.2, 19.4±0.2, 20.9±0.2, 23.7±0.2 and 24.5±0.2 degrees.
A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier, diluent, excipient or adjuvant.
Dependencies are inferred from the claim text.