Syncope prediction using cardiac acceleration information

A medical device system, comprising:

• a signal receiver circuit configured to receive physiologic information of a patient, the physiologic information including cardiac acceleration information and blood pressure information of the patient;
• and
• an assessment circuit configured to:
• determine a syncope metric for the patient as a function of cardiac acceleration information and the blood pressure information;
• determine an indication of a worsening risk of syncope or a syncope event for the patient using the determined syncope metric;
• and
• provide the determined indication of the worsening risk of syncope or the syncope event for the patient to a user or a process.