Hybrid bioelectronic/engineered cell wearable system for therapeutic agents delivery and applications thereof

A hybrid bioelectronic wearable device containing engineered cells for delivery of therapeutic agent to a subject, the device comprising:

• a cell cartridge containing at least one type of engineered cells, wherein each of the engineered cells contains an optogenetic system;
• an optical stimulating system disposed adjacent to the cell cartridge, wherein the optical stimulating system has at least one light source, wherein the optogenetic systems of the engineered cells are configured to receive a light generated from the at least one light source such that the generated light operably controls production of at least one type of therapeutic agent and a reporter agent by the engineered cells;
• a media cartridge in fluid communication with the cell cartridge providing cell media to the cell cartridge;
• a pump in fluid communication with the media cartridge and the cell cartridge, wherein the pump is configured to pump the cell media from the media cartridge into the cell cartridge;
• a cannula having a first cannula end in fluid communication with the cell cartridge and a second cannula end in fluid communication with the subject;
• and
• a controller in communication with the optical stimulating system and the sensing system, wherein the controller is configured to control the production of the at least one type of therapeutic agent according to a control algorithm.