Surgical drain for collection and preservation of tumor-associated biomarkers in surgical drain fluid
AssigneeWashington University
InventorsJose Zevallos, Ricardo Ramirez, Benjamin Wahle, Aadel Chaudhuri
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Abstract
A surgical drainage system is disclosed that includes an assay device operatively coupled to a surgical drainage tube. The drainage tube is configured for implantation within a surgical bed of a subject to drain surgical drain fluid out of the surgical bed. The assay device is configured to detect at least one analyte within the drainage fluid. The at least one analyte is indicative of a surgical bed condition.
Claims28
A surgical drainage system, comprising a device operatively coupled to a surgical drainage tube, the drainage tube configured for implantation within a surgical bed of a subject to drain surgical drain fluid out of the surgical bed, the device configured to detect at least one analyte within the drainage fluid, wherein the analyte is indicative of a condition.
The system of any preceding claim, wherein the assay device comprises a lateral flow antigen test.
The system of any preceding claim, wherein the assay device further comprises a replaceable cartridge housing the lateral flow antigen test.
The system of any preceding claim, wherein the at least one analyte detected by the assay device comprises at least one biomarker indicative of the presence of at least one of bacteria, chyle, blood, bile, and any combination thereof.
The system of any preceding claim, wherein the at least one biomarker is selected from lipase, protease, peptidase, amylase, pepsin, trypsin, chymotrypsin, carboxypeptidase, elastase, phospholipase, lactase, maltase, sucrase, triglyceride, chylomicron, bilirubin, and any combination thereof.
The system of any preceding claim, wherein detection of the at least one analyte by the assay device indicates a surgical bed condition selected from an infection within the surgical bed, a formation of a fistula, a chyle leak, a bile leak, an anastomotic leak, and any combination thereof.
A surgical drainage system, comprising a surgical drainage tube comprising a proximal portion configured for implantation within a surgical bed of a subject and a distal portion to drain surgical drain fluid out of the surgical bed through an inner lumen defined within the proximal and distal portions of the surgical drainage tube, wherein at least a portion of the lumen is coated with a nucleic acid preservation agent.
Dependencies are inferred from the claim text.