Antimicrobial eluting airway devices
AssigneeThe Children's Hospital of Philadelphia
InventorsRiccardo L. GOTTARDI, Matthew R. ARONSON
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Abstract
The present disclosure provides improved airway intervention devices that are coated with a material and contain an antimicrobial peptide. The devices are useful in controlling the microbial flora of the airway and preventing infections and conditions such as subglottic stenosis, pneumonia (VAP), laryngeal infection, post-operative dressing/packing-induced infection, upper airway infection, rhinosinusitis, choanal atresia, vocal fold injury and paralysis.
Claims26
An airway intervention device where a surface of said device is coated with a material comprising one or more anti-microbial peptides (AMPs) and one or more hydrophobic and/or natural polymers.
A method of preparing a coated airway intervention device comprising:
- (a) providing an airway intervention device;
- (b) immersing said device in an emulsion comprising one or more hydrophobic or natural polymers and one or more anti-microbial peptides (AMPs) to coat said device;
- (c) repeating step (b) at least once, optionally twice;
- and
- (d) drying said coated device.
Dependencies are inferred from the claim text.