Biosynthetic devices
AssigneeElastagen Pty. Limited
InventorsAnthony Steven Weiss, Suzanne Marie Mithieux
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Abstract
This invention provides a method for producing a device having elastic fiber arranged thereon. The method includes maintaining a cell culture including cells (for example, fibroblasts), cell medium and tropoelastin in conditions enabling the cells to form elastic fiber from the tropoelastin, and contacting a device with the cell culture to enable elastic fiber formed by the cells to be deposited onto the device, thereby producing a device having elastic fibers arranged thereon.
Claims17
A method for producing a device having elastic fiber arranged thereon including maintaining a cell culture including cells, cell medium and tropoelastin in conditions enabling the cells to form elastic fiber from the tropoelastin and contacting a device with the cell culture to enable elastic fiber formed by the cells to be deposited onto the device, thereby producing a device having elastic fibers arranged thereon.
The method of any one of the preceding claims wherein at least one surface of the device is contacted with cells of the cell culture.
The method of any one of the preceding claims wherein the device is includes collagen.
The method of anyone of the preceding claims wherein the device is in the form of a sheet, layer or tube.
The method of any one of the preceding claims wherein the device is porous.
The method of any one of the preceding claims wherein the cell is a fibroblast.
The method of any one of the preceding claims wherein the cell medium is, or includes a conditioned cell medium.
The method of any one of the preceding claims wherein the cell medium includes one or more of the proteins in Table 1 as described herein.
A device having elastic fibers arranged thereon produced by the method of any one of the preceding claims.
Dependencies are inferred from the claim text.