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US 2024/0189458 A1Published application
Methods for in vivo delivery of microbes to human microenvironments
AssigneesWilliam Marsh Rice University, Baylor College of Medicine
InventorsJeffrey TABOR, Omid VEISEH, Robert BRITTON, Moshe BARUCH, Annie GOODWIN, Elena MUSTEATA, Michael DOERFERT, Samira AGHLARA-FOTOVAT, Maxwell HUNT
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Abstract
The present disclosure provides compositions comprising encapsulated engineered bacteria. The bacteria may be engineered to act as sensors of biomarkers, such as inflammation, as well as to produce diagnostic or therapeutic agents.
Claims108
A device comprising engineered bacteria encapsulated in a hydrogel matrix.
The device of claim 53, wherein the AMPs are RK-31, KS-27, KS-30, TLN-58, LL-29, ALL-38, GNLY, CCL20, TCP, KR-20, CCL-19, hBD3, and/or NPY.
Dependencies are inferred from the claim text.