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AssigneePoseida Therapeutics, Inc.
InventorsJoshua RYCHAK, Sean ESSEX, Matthew BUTCHER, Peter GRIFFIN, Blair MADISON, Renata MARTIN, Neha PARAYATH, Michael J. BENNETT, Khalid A. HAJJ, Oscar ALVAREZ, Dan J. SMITH
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The present disclosure provides compositions and methods for the genetic modification of cells, including, but not limited to, hepatocytes. The compositions and methods can comprise lipid nanoparticles, wherein the lipid nanoparticles comprise at least one bioreducible ionizable cationic lipid, at least one structural lipid, at least one phospholipid and at least one PEGylated lipid.
A composition comprising at least one lipid nanoparticle comprising between about 53% to about 60% of ssPalmO-Ph-P4C2 by moles;
The composition of any of the preceding claims, wherein the at least one nucleic acid molecule comprises a nucleic acid sequence encoding at least one therapeutic protein.
A method of delivering at least one nucleic acid to at least one cell comprising contacting the at least one cell with at least one composition of any of the preceding claims.
A method of genetically modifying at least one cell comprising contacting the at least one cell with at least one composition of any of the preceding claims.
Dependencies are inferred from the claim text.