A delta-opioid receptor targeted agent for molecular imaging and immunotherapy of cancer

A compound of Formula I:

• wherein
• X is a kinase inhibitor or JAK/STAT3 inhibitor;
• Z is a linker fragment;
• and Ab is an antibody;
• and
• wherein said linker fragment Z is a single atom or is selected from the group consisting of a substituted carbon, an oxygen, a substituted or an unsubstituted sulphur, a substituted nitrogen, a substituted phosphorous, a substituted or an unsubstituted alkyl, a substituted or an unsubstituted alkylene, a substituted alkenyl, a substituted alkynyl chain, a substituted or an unsubstituted alkyne chain, a substituted or an unsubstituted alkoxyl chain, an ether, an amine, an amide, a sulfonamide, an alkylamine, a thioether, a carboxylate, a polyethylene, a polypropylene, and a derivative or a combination thereof.

A compound of Formula II:

• wherein
• Y is a kinase inhibitor or JAK/STAT3 inhibitor;
• Z is a linker fragment;
• M is any metal of the lanthanide series of the Periodic Table;
• Ab is an antibody;
• and
• wherein aid linker fragment Z is a single atom or is selected form the group consisting a substituted carbon, an oxygen, a substituted or an unsubstituted sulphur, a substituted nitrogen, a substituted phosphorous, a substituted or an unsubstituted alkyl, a substituted alkenyl, a substituted alkynyl chain, a substituted or an unsubstituted alkylene, a substituted or an unsubstituted alkyne chain, a substituted or an unsubstituted alkoxyl chain, an ether, an amine, an amide, a sulfonamide, an alkylamine, a thioether, a carboxylate, a polyethylene, a polypropylene, and a derivative or a combination thereof.

An antibody conjugated to one or more moieties of X:

• wherein
• X is a kinase inhibitor or JAK/STAT3 inhibitor;
• Z is a linker fragment;
• Ab is an antibody;
• wherein said linker fragment Z is a single atom or is selected from the group consisting of a substituted carbon, an oxygen, a substituted or an unsubstituted sulphur, a substituted nitrogen, a substituted phosphorous, a substituted or an unsubstituted alkyl, a substituted or an unsubstituted alkylene, a substituted alkenyl, a substituted alkynyl chain, a substituted or an unsubstituted alkyne chain, a substituted or an unsubstituted alkoxyl chain, an ether, an amine, an amide, a sulfonamide, an alkylamine, a thioether, a carboxylate, a polyethylene, a polypropylene, and a derivative or a combination thereof;
• and
• X is (X)n wherein n is an integer of from 1 to 50.

An antibody conjugated to one or more moieties of Y:

• wherein
• Y is a kinase inhibitor or JAK/STAT3 inhibitor;
• Z is a linker fragment;
• M is any metal of the lanthanide series of the Periodic Table;
• wherein said linker fragment Z is a single atom or is selected form the group consisting a substituted carbon, an oxygen, a substituted or an unsubstituted sulphur, a substituted nitrogen, a substituted phosphorous, a substituted or an unsubstituted alkyl, a substituted alkenyl, a substituted alkynyl chain, a substituted or an unsubstituted alkylene, a substituted or an unsubstituted alkyne chain, a substituted or an unsubstituted alkoxyl chain, an ether, an amine, an amide, a sulfonamide, an alkylamine, a thioether, a carboxylate, a polyethylene, a polypropylene, and a derivative or a combination thereof;
• Y is (Y)n wherein n is an integer of from 1 to 50;
• and
• Ab is an antibody.