Chimeric antigen receptor with modified hinge and transmembrane domain and uses thereof
AssigneeOrgenesis Inc.
InventorsBUO CHEN, Xiangqun LI
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Abstract
The present disclosure provides a chimeric antigen receptor (CAR) molecule comprising a modified hinge and transmembrane domain (HTM-1), wherein the modified hinge and transmembrane domain comprises the amino acid sequence of SEQ ID NO:2. Cells expressing CAR with the modified HTM-1 domain disclosed herein are expected to have enhanced anti-tumor activities with reduced release of pro-inflammatory cytokines.
Claims13
An isolated chimeric antigen receptor (CAR) molecule comprising an antigen binding domain, a hinge and transmembrane domain, a costimulatory domain, and an intracellular signaling domain, wherein the hinge and transmembrane domain comprises the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.