Pseudorabies virus vaccine
AssigneeZoetis Services LLC
InventorsQiaoRan LIU, JinAn HUANG, YiBo KONG, Dong SUN
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Abstract
This disclosure provides an attenuated suid herpesvirus 1 (a Pseudorabies virus) wherein the TK, gI and gE genes thereof are modified relative to a parent field strain, such that the resultant virus is safe and effective for use as a live vaccine that protects swine animals from challenge with a virulent Pseudorabies virus.
Claims31
An attenuated suid herpesvirus 1 (a Pseudorabies virus) wherein the TK, gI and gE genes thereof are modified relative to a parent field strain, such that the resultant virus is safe and effective for use as a live vaccine that protects swine animals from challenge with a virulent Pseudorabies virus, and wherein said parent strain is selected from the group consisting of:
- strain FS18 (SEQ ID NO:1);
- strain JS2012 (SEQ ID NO:2);
- strain TJ (GenBank accession KJ789182);
- strain HeN1 (GenBank accession KP098534);
- strain HUJ8 (GenBank accession KT824771);
- strain HN1201 (GenBank accession KP722022), and any strain that is encoded from a nucleotide sequence that is at least 85% identical to SEQ ID:
- NO.1 or SEQ ID NO:2.
An attenuated suid herpesvirus I (Pseudorabies virus) that is derived from strain FS18 (SEQ ID NO:1);
- strain JS2012 (SEQ ID NO:2), strain TJ (GenBank accession KJ789182), strain HeN1 (GenBank accession KP098534), strain HUJ8 (GenBank accession KT824771) or strain HN1201 (GenBank accession KP722022), or any strain that is encoded from a nucleotides sequence that is at least 85% identical to SEQ ID:
- NO.1 or SEQ ID NO:2, wherein said attenuate is encoded from a DNA sequence that comprises the following deletions:
- for the gE gene, all of the nucleotides of the ORF are deleted;
- for the gI gene, at least nucleotides 269-1101 of the 1101 nucleotide ORF are deleted;
- and
- for the TK gene, from the 963 nucleotide ORF, a deletion is selected from the nucleotide sequence consisting of positions 526-607, 480-846, 280-723 and 364-615.
Dependencies are inferred from the claim text.