Virus vaccine based on virus surface engineering providing increased immunity
AssigneeThe Industry & Academic Cooperation in Chungnam National University (IAC)
InventorHyun-Jin SHIN
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Abstract
The present disclosure relates to an immune-enhanced virus vaccine based on virus surface engineering. A linker peptide according to one aspect has the property of being attachable to a virus, and may be used as a linker that may effectively bind an immune-enhancing substance, which activates the immune system, to the surface of the virus, and thus may improve the immunogenicity of the vaccine. By incorporating the linker peptide into virus surface engineering technology, an immune-enhancing substance may be attached to the surface of the virus, which may be useful in an immune-enhanced vaccine platform.
Claims11
A linker peptide consisting of an amino acid sequence of SEQ ID NO:
- 1.
A fusion protein comprising:
- a linker peptide consisting of an amino acid sequence of SEQ ID NO:
- 1;
- and
- an immune-enhancing substance connected to a C-terminus of the linker peptide.
A vaccine composition comprising:
- an infectious virus-derived antigen;
- and
- a fusion protein including a linker peptide consisting of an amino acid sequence of SEQ ID NO:
- 1 and an immune-enhancing substance connected to a C-terminus of the linker peptide.
The vaccine composition of claim 9, wherein an N-terminus of the linker peptide is connected to an infectious virus-derived antigen.
Dependencies are inferred from the claim text.