DNA Monoclonal Antibodies Targeting Checkpoint Molecules
AssigneesThe Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
InventorsDavid B. Weiner, Kar Muthumani, Niranjan Sardesai
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Abstract
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets an immune checkpoint molecule. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
Claims20
A composition for generating a synthetic antibody in a subject comprising one or more nucleic acid molecules encoding one or more antibodies or fragments thereof, wherein the one or more antibodies or fragments target at least one immune checkpoint molecule.
A method of increasing an immune response in a subject in need thereof by administering a combination of a synthetic antigen and an immune checkpoint inhibitor, wherein the immune checkpoint inhibitor is a synthetic antibody, wherein the administering step comprises:
- administering to the subject a prime vaccination and a boost vaccination of synthetic antigen, and
- subsequent to the boost vaccination, administering to the subject an immune checkpoint inhibitor.
Dependencies are inferred from the claim text.