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US 2024/0189404 A1Published application
Immunogenic peptides with extended oxidoreductase motifs
AssigneeImcyse SA
InventorMilos ERAK
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Abstract
The invention relates to immunogenic peptides comprising MHC class II T-cell epitopes and oxidoreductase motifs with increased activity, and their use in regulating the immune response in subjects.
Claims23
An immunogenic peptide, said immunogenic peptide comprising:
- a) an oxidoreductase motif,
- b) an MHC class II T-cell epitope of an antigenic protein, and
- c) a linker between a) and b) of between 0 and 7 amino acids,
- wherein said oxidoreductase motif has the following sequence:
- Z(B)n[CST]XmC- or Z(B)nCXm[CST]-;
- wherein Z is any amino acid or non-natural amino acid, excluding basic amino acids comprising R (Arginine), K (Lysine) and H (Histidine), and excluding amino acids D (Aspartate), W (Tryptophane), E (Glutamate), and A (Alanine);
- wherein (B) is any amino acid;
- wherein n is an integer of 0 to 2;
- wherein Cis Cysteine, S is Serine and T is Threonine;
- wherein X is any amino acid;
- wherein m is 2, 0, 1, or 3;
- and
- wherein the hyphen (-) in said oxidoreductase motif indicates the point of attachment of the oxidoreductase motif to the N-terminal end of the linker (c) or the epitope (b), or to the C-terminal end of the linker (c) or the epitope (b).
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Dependencies are inferred from the claim text.