Compositions, systems, and methods for treating or reducing hypoxia-ischemia induced brain damage and neurobehavioral dysfunction in neonates
AssigneeUniversity of Mississippi Medical Center
InventorsLir-Wan Fan, Abhay Jyotindrabhai Bhatt
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Abstract
A method for treating or reducing a likelihood of hypoxia-ischemia induced brain damage and neurobehavioral dysfunction in neonates utilizes a relative high dose of nasally administered insulin. In one aspect, the method includes intranasally administering, to a neonate in need thereof, an effective dose of insulin comprising between 350 U to 2000 U insulin.
Claims16
A method for treating or reducing a likelihood of hypoxia-ischemia induced brain damage and neurobehavioral dysfunction in preterm neonates, comprising intranasally administering, to a preterm neonate in need thereof, an effective dose of insulin comprising between 350 U to 2000 U insulin.
A method for treating or reducing a likelihood of hypoxia-ischemia induced brain damage and neurobehavioral dysfunction in preterm neonates, comprising:
- identifying a preterm neonate having experienced, or who is suspected as having experienced, a hypoxic-ischemic event;
- intranasally administering between 175 U and 1000 U insulin to each nare of the neonate without causing systemic hypoglycemia;
- and
- reducing a likelihood of hypoxia-ischemia induced brain damage and neurobehavioral dysfunction in the neonate.
Dependencies are inferred from the claim text.