Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients
AssigneeEnsoma, Inc.
InventorVeit Schmelmer
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Abstract
The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, such as a donor with multiple myeloma, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a patient with multiple myeloma for performing an autologous stem cell transplant to treat the patient's multiple myeloma.
Claims20
-129. (canceled)
A method of mobilizing a population of hematopoietic stem or progenitor cells from the bone marrow of a mammalian donor into peripheral blood, the method comprising administering to the donor a CXCR2 agonist selected from the group consisting of Gro-β, Gro-β T, and variants thereof at a dose of from about 0.001 mg/kg to about 0.1 mg/kg, wherein the CXCR2 agonist is administered over a period of time of less than about 20 minutes.
Dependencies are inferred from the claim text.