US 2024/0189385 A1 · KEAP1/NRF2 PROTEIN-LIKE POLYMERS

Abstract

In an aspect, the invention provides therapeutic agents comprising brush polymers that address challenges associated with conventional administration of free therapeutic peptides. In an embodiment, for example, the invention provides brush polymers incorporating one or more therapeutic peptides comprising a sequence having 75% or greater sequence identity of SEQ ID NO: 1 (LDEETGEFL) as side chain moieties. Therapeutic agents of the invention comprising brush polymers include high-density brush polymers including cross-linked brush polymers, brush block copolymers, and brush random copolymers. In an embodiment, brush polymers of the invention exhibit proteolysis-resistant characteristics and maintain their biological function during formulation and administration. The invention also includes methods of making and using therapeutic agents comprising brush polymers.

Claims50

Dependent claims

A peptide having from 11 to 16 amino acid residues comprising a sequence having 85% or greater sequence identity of SEQ ID NO:

1 (LDEETGEFL), wherein the peptide further comprises a charge modulating domain having from 2 to 7 amino acid residues.

A polymer comprising:

a first polymer segment comprising at least 2 first repeating units;
wherein each of the first repeating units of the first polymer segment comprises a first polymer backbone group directly or indirectly covalently linked to a first polymer side chain group comprising a peptide;
wherein the peptide comprises a sequence having 75% or greater sequence identity of SEQ ID NO:
1 (LDEETGEFL).

1 more element

Dependencies are inferred from the claim text.

Keap1/nrf2 protein-like polymers

Life of this patent

Keap1/nrf2 protein-like polymers

Life of this patent

Abstract

Claims50