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US 2024/0189374 A1Published application
Adenovirus for treatment of cancer
AssigneeElicera Therapeutics AB
InventorDi YU
Life of this patent
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Abstract
The invention relates to an adenovirus comprising a nucleic acid sequence encoding a Helicobacter pylori neutrophil-activating protein (NAP) and/or a nucleic acid sequence encoding an immunologically equivalent fragment of NAP and a nucleic acid sequence encoding an immunomodulator capable of inducing an immune response in a subject. The adenovirus has enhanced clinical effects in terms of delaying tumor growth and prolonging survival.
Claims26
-25. (canceled)
An adenovirus comprising:
- a nucleic acid sequence encoding a Helicobacter pylori neutrophil-activating protein (NAP) and/or a nucleic acid sequence encoding an immunologically equivalent fragment of NAP, wherein the immunologically equivalent fragment of NAP is a fragment including at least one polypeptide domain of at least 20 amino acid residues of NAP;
- and
- a nucleic acid sequence encoding an immunomodulator capable of inducing an immune response in a subject.
Dependencies are inferred from the claim text.