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US 2024/0189360 A1Published application
Compositions and methods to improve the homing and grafting of hematopoetic stem cells
Assignee7 Hills Pharma LLC
InventorUpendra K. Marathi
Life of this patent
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Abstract
Methods comprising administering a composition including hematopoietic stem cells and one or more integrin activators or agonists, wherein the integrin activators or agonists improve homing, infiltrating, grafting, and retention of hematopoietic stem cells, especially, hematopoietic stem cells derived from umbilical cord blood, to reconstitute bone morrow tissue compromised by myeloablation therapy or by a hematologic cancer or a genetic disorder.
Claims20
A method comprising:
- administering a composition to a target tissue site of a patient, the composition comprising:
- a therapeutical amount of hematopoietic stem cells (HSCs), and
- an effective amount of one or more integrin activating or agonist compounds,
- wherein the effective amount is between about 1 fM and about 300 μM,
- wherein the therapeutical amount of HSCs is about 106 cells, and
- wherein the one or more integrin activating or agonist compounds enhance binding of surface integrins on the HSCs to their respective ligands and improve homing, infiltrating, grafting, and retention of HSCs to reconstitute bone morrow tissue compromised by myeloablation therapy or by a hematologic cancer or genetic disorder.
3 more elements
Dependencies are inferred from the claim text.