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AssigneeBoard of Regents, The University of Texas System
InventorsKaty REZVANI, Elizabeth SHPALL, Rafet BASAR, May DAHER, Sunil ACHARYA, Nadima UPRETY, Ana Karen NUNEZ CORTES, Emily ENSLEY, David MARIN COSTA
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Embodiments of the disclosure include methods and compositions related to targeting of CD5-expressing cells with particular engineered receptors. In specific embodiments, NK cells are specifically engineered to bind the CD5 antigen using particular chimeric antigen receptor constructs. In certain embodiments, vectors that express the CD5-targeting CARs also express particular a suicide gene and/or one or more particular cytokines.
An expression construct comprising sequence that encodes a CD5-specific engineered receptor, wherein said receptor comprises one of the following:
The expression construct, wherein the CD5-specific engineered receptor is a CAR.
Dependencies are inferred from the claim text.