Hypoimmunogenic cells having targeted modifications in mhc class-i genes and methods of use
OwnerYou ZHOU, Matthew COOPER +1inventors
InventorsYou ZHOU, Matthew COOPER, Elizabeth SCHRAMM
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Abstract
The present disclosure provides compositions of genetically modified cells that are hypoimmunogenic. The present disclosure also provides methods of making hypoimmunogenic cells and using hypoimmunogenic cells for the treatment of cancer and autoimmune conditions.
Claims23
An hypoimmunogenic cell comprising one or more genetic modifications in one or more HLA genes selected from the group consisting of:
- HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, and HLA-G, wherein the modification (i) reduces or prevents a CD8+ T cell-mediated response against the hypoimmunogenic cell, and/or (ii) reduces or prevents an NK cell-mediated response against the hypoimmunogenic cell.
A method of making a hypoimmunogenic cell, the method comprising introducing into a cell one or more genetic modifications in one or more HLA genes selected from the group consisting of:
- HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, and HLA-G;
- wherein the modification (i) reduces or prevents a CD8+ T cell-mediated response against the hypoimmunogenic cell, and/or (ii) reduces or prevents an NK cell-mediated response against the hypoimmunogenic cell.
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Dependencies are inferred from the claim text.