T-cell receptors specific for both rac1- and rac2-derived mutated epitopes

An isolated antigen binding protein (ABP) which specifically binds to a mutated RAC1 and/or RAC2 derived antigenic peptide, or to a variant thereof, and wherein the isolated ABP comprises a T cell receptor (TCR) α or γ chain;

• and/or a TCR β or δ chain;
• wherein the TCR α or γ chain comprises a complementary determining region (CDR)3 having an amino acid sequence with at least 80% sequence identity to, or having no more than three amino acid substitution(s), deletion(s) or insertion(s) compared to, a sequence selected from SEQ ID Nos:
• 3 and 11;
• and/or wherein the TCR β or δ chain comprises a CDR3 having an amino acid sequence with at least 80% sequence identity to, or having no more than three amino acid substitution(s), deletion(s) or insertion(s) compared to, a sequence selected from SEQ ID Nos:
• 7 and 15.