Ecm hydrogel for treating esophageal inflammation
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsStephen Francis Badylak, Juan Diego Naranjo Gutierrez, Lindsey Tamiko Saldin
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Abstract
Methods are disclosed for inhibiting esophageal inflammation in a subject, that include administering to the esophagus of the subject with esophageal inflammation a therapeutically effective amount of an extracellular matrix (ECM) hydrogel. Methods are also disclosed for reducing esophageal stricture. Compositions are disclosed that include an esophageal extracellular matrix (ECM) hydrogel.
Claims22
A method for inhibiting esophageal inflammation or reducing esophageal stricture in a subject, comprising:
- administering to the esophagus of the subject a therapeutically effective amount of an extracellular matrix (ECM) digest solution comprising a hydrated, decellularized, enzymatically digested ECM derived from esophageal tissue, wherein the ECM has not been cross-linked or dialyzed, wherein the ECM digest solution has a pH of about 7.2 to about 7.8 and forms a gel when warmed to a temperature greater than 25° C.,
- thereby inhibiting esophageal inflammation or reducing esophageal stricture in the subject.
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Dependencies are inferred from the claim text.