Use of microrna-146a and nanoceria conjugate to improve wound healing and promote tissue regeneration
AssigneesThe Regents of the University of Colorado, a body corporate, University of Central Florida Research Foundation, Inc., The Trustees of the University of Pennsylvania
InventorsKenneth Liechty, Sudipta Seal, Robert Gorman
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Abstract
The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.
Claims20
A method for treating or preventing oxidative stress subject in need thereof, the method in a comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising microRNA-conjugated cerium oxide nanoparticles (CNPs);
- wherein the microRNA is miRNA-146a covalently attached at a 3′ end to the cerium oxide nanoparticle.
A method for treating or preventing inflammation in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising microRNA-conjugated cerium oxide nanoparticles (CNPs);
- wherein the microRNA is miRNA 146a covalently attached at a 3′ end to the cerium oxide nanoparticle via an amide linkage.
Dependencies are inferred from the claim text.