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AssigneeJulius-Maximilians-UniversitäT WüRzburg
InventorsThomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
1-139. (canceled)
A method for diagnosing fibrosis comprising measuring the expression of miR-21 in a sample from a patient supposed to suffer from fibrosis, wherein an elevated level of miR-21 in comparison to a control sample indicates fibrosis or a predisposition thereof.
A method for screening a pharmaceutically active compound for the treatment and/or the prevention of fibrosis or a predisposition thereof, comprising
Dependencies are inferred from the claim text.