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US 2024/0189335 A1Published application
N4-hydroxycytidine and derivatives and anti-viral uses related thereto
AssigneeEmory University
InventorsGeorge R. PAINTER, Gregory R. BLUEMLING, Michael G. NATCHUS, David GUTHRIE
Life of this patent
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Abstract
This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.
Claims14
1-60. (canceled)
A compound of Formula VI,
- or a pharmaceutical or physiological salt thereof, wherein
- R1, R2, and R3 are each independently selected from the following:
- optionally substituted carbonates, optionally substituted acetal, and optionally substituted hemiacetal,
- wherein R1, R2, and R3 are optionally substituted with one or more, the same or different, R10;
- R6 is alkyl, carbocyclyl, heterocarbocyclyl, cycloalkyl, alkoxy, carbocycloxy, heterocarbocycloxy, cycloalkoxy, wherein R6 is optionally substituted with one or more, the same or different, R10;
- R10 is alkyl, amino, carbocyclyl, heterocarbocyclyl, cycloalkyl, alkoxy, carbocycloxy, heterocarbocycloxy, cycloalkoxy, or carbonyl, wherein R10 is optionally substituted with one or more, the same or different, R11;
- R11 is hydroxy, alkyl, carbocyclyl, heterocarbocyclyl, cycloalkyl, alkoxy, carbocycloxy, heterocarbocycloxy, cycloalkoxy, or carbonyl.
4 more elements
Dependencies are inferred from the claim text.