Compositions and Methods for Inhibiting and Treating Viral Infections
AssigneeThe Regents of the University of California
InventorTheodoros Kelesidis
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Abstract
Disclosed herein are methods of using (a) one or more mitochondrial targeted antioxidants, (b) one or more Nrf2 agonists, and (c) combinations of one or more mitochondrial targeted antioxidants and one or more Nrf2 agonists, to prevent, inhibit, and/or treat infections and symptoms caused by infection by a virus. such as those belonging to the Orthomyxoviridae family, the Picornaviridae family, and the Pneumoviridae family of viruses.
Claims20
A method of preventing, inhibiting, or reducing infection by, an inflammatory response caused by infection by, or apoptosis caused by infection by a virus in a cell or a subject or treating the subject for a viral disease caused by infection by the virus, which comprises, consists essentially of, or consists of:
- (a) administering one or more mitochondrial targeted antioxidants to the cell or the subject, wherein the virus is not a coronavirus or a respiratory syncytial virus (RSV);
- or (b) administering one or more Nrf2 agonists to the cell or the subject, wherein the virus is not a coronavirus;
- or (c) administering a combination of one or more mitochondrial targeted antioxidants and one or more Nrf2 agonists to the cell or the subject, wherein the virus is not a coronavirus.
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A composition comprising a combination of one or more mitochondrial targeted antioxidants plus one or more Nrf2 agonists.
Dependencies are inferred from the claim text.