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US 2024/0189326 A1Published application
Tetracycline compositions
AssigneeMelinta Subsidiary Corp.
InventorsDavid C. GRIFFITH, Serge Henri BOYER, Scott J. HECKER, Michael N. DUDLEY
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Abstract
The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
Claims30
An intravenous formulation consisting essentially of:
- an aqueous solution of a single antibiotic ingredient and a magnesium cation;
- wherein:
- the single antibiotic ingredient is minocycline;
- the molar ratio of the magnesium cation to the minocycline is greater than 4:1;
- the formulation has a pH greater than 4 and less than 7;
- and
- administration of the intravenous formulation results in reduced injection site hemolysis relative to intravenous administration of a control intravenous formulation that does not include magnesium.
4 more elements
Dependencies are inferred from the claim text.