Targeting the tlk1/nek1 axis in prostate cancer

A pharmaceutical composition comprising:

• (a) a first therapeutic comprising a TLK1B inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, wherein the TLK1B inhibitor is a phenothiazine (PTH) antipsychotic selected from the group consisting of:
• Thioridazine (THD), Perphenazine (PPH), Trifloroperazine (TFP), Promazine (PMZ), 4-(2-(10H-phenothiazin-10-yl) ethyl) morpholine (J54), 10-methyl-10H-phenothiazine (J56), J3-50, J3-51, J3-54, J3-55, JS-56, J3-65, and J3-66;
• and
• (b) a second therapeutic including an antiandrogen or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof.