Rifamycin analogs in combination with vancomycin and uses thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsThomas NITTOLI, Anna ZUMSTEG
Life of this patent
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Abstract
The disclosure relates to rifamycin analog compounds in combination with vancomycin, and pharmaceutical compositions and dosage forms comprising same, capable of inhibiting bacterial growth (e.g., S. aureus growth) and treating bacterial infections (e.g., S. aureus infections). The disclosure further relates to methods of use thereof to inhibit bacterial growth, treat bacterial infections. and treat disease with rifamycin analog compounds in combination with vancomycin. The disclosure further relates to methods of enhancing efficacy of rifamycin analog compounds and/or vancomycin.
Claims46
A method of preventing or inhibiting growth of a bacterium comprising administering an effective amount of:
- a) a compound selected from
- or a pharmaceutically acceptable salt thereof, and
- b) vancomycin or a derivative thereof, or a pharmaceutically acceptable salt thereof.
A method of treating a bacterial infection in a subject in need of such treatment comprising administering to the subject an effective amount of:
- a) a compound selected from
- or a pharmaceutically acceptable salt thereof, and
- b) vancomycin or a derivative thereof, or a pharmaceutically acceptable salt thereof.
A method of preventing or treating a disease in a subject in need thereof comprising administering to the subject an effective amount of a) a compound selected from
- or a pharmaceutically acceptable salt thereot, and
- b) vancomycin or a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the disease is selected from cellulitis, bacteremia, dermonecrosis, eyelid infection, eye infection, neonatal conjunctivitis, osteomyelitis, impetigo, boils, scalded skin syndrome, food poisoning, pneumonia, surgical infection, urinary tract infection, burn infection, meningitis, endocarditis, septicemia, toxic shock syndrome, septic arthritis, mastitis, infection associated with a prosthetic joint, infection associated with a catheter, and infection associated with an implant.
A method of enhancing efficacy of vancomycin or a derivative thereof comprising administering to a subject in need thereof an effective amount of:
- a) a compound selected from
- or a pharmaceutically acceptable salt thereof, in combination with
- b) vancomycin or a derivative thereof, or a pharmaceutically acceptable salt thereof.
A method of enhancing efficacy of a compound selected from
- or a pharmaceutically acceptable salt thereof, the method comprising administering a subject in need thereof an effective amount of the compound (I) or (II) in combination with vancomycin or a derivative thereof, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a) a compound selected from
- or a pharmaceutically acceptable salt thereof,
- b) vancomycin or a derivative thereof, or a pharmaceutically acceptable salt thereof, and
- c) a pharmaceutically acceptable carrier.
A pharmaceutical dosage form comprising a) a compound selected from
- or a pharmaceutically acceptable salt thereof,
- b) vancomycin or a derivative thereof, or a pharmaceutically acceptable salt thereof, and
- c) a pharmaceutically acceptable vehicle.
A kit comprising a) a first container comprising a compound selected from
- or a pharmaceutically acceptable salt thereof,
- b) a second container comprising vancomycin or a derivative thereof, or a pharmaceutically acceptable salt thereof, and
- c) instructions for administration of the compound (I) or (II) and the vancomycin or a derivative thereof.
Dependencies are inferred from the claim text.