Methods and compositions for prevention and treatment of cardiac hypertrophy
AssigneeUniversity of Hawaii
InventorAlexander Stokes
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Abstract
Methods are provided of treating cardiac hypertrophy in a mammalian subject comprising administering to the subject an anti-hypertrophic effective amount of an ion channel TR-PV1 inhibitor. The methods include treatment of a symptom of cardiac hypertrophy in the subject comprises cardiac remodeling, cardiac fibrosis, apoptosis, hypertension, or heart failure
Claims21
1-12. (canceled)
A method of reducing the plasma concentration of a marker of cardiac hypertrophy in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.
A method of reducing the plasma concentration of atrial natriuretic peptide (ANP) in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.
A method of maintaining or reducing heart weight or size in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.
A method of reducing and or reversing the physical and functional adaptations of cardiac hypertrophy in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.
Dependencies are inferred from the claim text.