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US 2024/0189286 A1Published application
Viral inhibitors, the synthesis thereof, and intermediates thereto
AssigneeTakeda Pharmaceutical Company Limited
InventorsJeffrey Scott DePue, Suresh Kumar Tipparaju, Helge Alfred Reisch, Datong Tang, Kishore Ramachandran
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Abstract
The present disclosure discloses compositions comprising maribavir, methods of providing the same, and compositions providing intermediates useful in providing maribavir.
Claims16
A method of treating a patient with post-transplant cytomegalovirus (CMV) infection and/or disease, the method comprising:
- administering to the patient a pharmaceutical composition comprising maribavir, or a pharmaceutically acceptable salt thereof, in an amount of about 400 mg orally twice daily,
- wherein the patient is a transplant recipient, wherein the CMV infection and/or disease is refractory to treatment with ganciclovir, valganciclovir, cidofovir or foscarnet,
- wherein the pharmaceutical composition comprises:
- (i) maribavir:
- or a pharmaceutically acceptable salt thereof;
- and
- (ii) one or more of the following, relative to maribavir:
- about 0.01% to about 0.1% w/w of Compound 2,
- or a pharmaceutically acceptable salt thereof;
- about 0.01% to about 0.1% w/w of Compound 3,
- or a pharmaceutically acceptable salt thereof;
- or
- about 0.01% to about 0.1% w/w of Compound 4:
- or a pharmaceutically accept salt thereof.
11 more elements
(canceled)
4-24. (canceled)
Dependencies are inferred from the claim text.