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US 2024/0189276 A1Published application
Compositions comprising lactate dehydrogenase-a inhibitors and methods of production and use thereof
AssigneeSouthwestern Oklahoma State University
InventorsHorrick Sharma, Pragya Sharma
Life of this patent
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Abstract
Compounds that incorporate a succinic acid scaffold are disclosed that inhibit Lactate dehydrogenase-A (LDHA). Also disclosed are pharmaceutical compositions containing these compounds. In addition, methods of using these compounds in methods of inhibiting LDHA expression and/or enzymatic activity in cells and methods of reducing viability of cancer cells are disclosed. Also disclosed are methods of treating a subject in need thereof with the pharmaceutical compositions containing one or more LDHA-inhibiting compounds.
Claims21
A composition, comprising:
- at least one compound, wherein the at least one compound is an inhibitor of Lactate dehydrogenase-A (LDHA), and wherein the at least one compound has a structure represented by Formula I:
- or an enantiomer, stereoisomer, or pharmaceutically acceptable salt thereof,
- wherein:
- R is H, an alkyl group, or a substituted phenyl group;
- R1 is selected from a phenyl group;
- an alkyl group;
- a substituted phenyl group;
- an aromatic ring;
- a heteroaromatic ring;
- a fused bicyclic group;
- a biphenyl group;
- or a 3-7 membered carbocyclic or alicyclic ring incorporating at least one heteroatom;
- R2 is selected from a phenyl group;
- a substituted phenyl group;
- an aromatic ring;
- a heteroaromatic ring;
- a bicyclic group;
- a tricyclic group;
- a 3-7 membered alicyclic ring incorporating at least one heteroatom;
- a carbocyclic ring;
- or a disubstituted carbocyclic ring;
- and
- Linker comprises at least one of an amide group;
- a reverse amide group;
- an ether group;
- an alkyl group;
- or a 3-7 membered carbocyclic, alicyclic, heterocyclic, aromatic, or heteroaromatic ring.
24 more elements
21-34. (canceled)
Dependencies are inferred from the claim text.