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US 2024/0189271 A1Published application
Pharmaceutical compositions of dimethyl fumarate
AssigneeArbor Pharmaceuticals, LLC
InventorsSami KARABORNI, Wei CHEN, Suresh Kumar MANTHATI
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Abstract
Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
Claims20
A dosage form for treating multiple sclerosis, comprising:
- (a) a therapeutically effective amount of dimethyl fumarate in solid form;
- (b) one or more compounds of Formula (V):
- isomers thereof and salts of any of the foregoing, wherein:
- each of R13 and R14 is independent chosen from hydrogen and methyl;
- and wherein the one or more compounds of Formula (V) are present in a combined total amount of less than 2% by weight based on total weight of the dimethyl fumarate;
- and
- (c) a pharmaceutically acceptable vehicle.
4 more elements
A dosage form for treating multiple sclerosis, comprising:
- (a) a therapeutically effective amount of dimethyl fumarate in solid form;
- (b) one or more compounds of Formula (VI):
- isomers thereof and salts of any of the foregoing, wherein:
- Q is —O—, —S—, —NH—, N(R17)— or C(R18)2—;
- each of R15 and R16 is independently chosen from hydrogen and methyl;
- R17 is alkyl;
- each R18 is independently hydrogen or alkyl;
- and
- wherein the one or more compounds of Formula (VI) are impurities and are present in a combined total amount of less than 2% by weight based on total weight of the dimethyl fumarate;
- and
- (c) a pharmaceutically acceptable vehicle.
8 more elements
Dependencies are inferred from the claim text.