Compositions and techniques for vaginal insertion

A method, comprising:

• applying, to a vagina of a subject, a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for inducing cervical ripening, wherein the composition, as applied, has a viscosity of at least 1.5 million cP.

A method, comprising:

• providing a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for inducing cervical ripening;
• and
• removing air from the composition.

A method, comprising:

• providing a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for inducing cervical ripening;
• and
• exposing the composition to a pressure of less than 100 mbar (absolute) for at least 30 minutes to form a gel.

A method, comprising:

• applying, to a vagina of a subject, a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for treating dysmenorrhea, wherein the composition, as applied, has a viscosity of at least 1.5 million cP.

A method, comprising:

• providing a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for treating dysmenorrhea;
• and
• removing air from the composition.

A method, comprising:

• providing a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for treating dysmenorrhea;
• and
• exposing the composition to a pressure of less than 100 mbar (absolute) for at least 30 minutes to form a gel.

A method, comprising:

• applying, to the vagina of a subject, a gel having a viscosity at room temperature of at least 1.5 million cP.

The kit of 211, further comprising one or more of instructions for inserting the applicator into the vagina and instructions for inducing cervical ripening, for treating dysmenorrhea, treating menorrhagia, or promoting cervical ripening by applying the applicator filled with the composition.

A method, comprising:

• applying, to a vagina of a subject, a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for treating menorrhagia, wherein the composition, as applied, has a viscosity of at least 1.5 million cP.

A method, comprising:

• providing a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for treating menorrhagia;
• and
• removing air from the composition.

A method, comprising:

• providing a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for treating menorrhagia;
• and
• exposing the composition to a pressure of less than 100 mbar (absolute) for at least 30 minutes to form a gel.

A method, comprising:

• providing a composition comprising a poloxamer, a stabilization polymer, and an active ingredient for treating menorrhagia;
• and
• exposing the composition to a pressure of less than 100 mbar (absolute) for at least 30 minutes to form a gel.

The method or composition of any one of the above claims, wherein the composition releases about 50% of the active ingredient in about 10 hours to about 50 hours.

The method or composition of any one of the above claims, wherein the composition releases about 80% of the active ingredient in about 30 hours to about 60 hours.

The method or composition of any one of the above claims, wherein the composition releases about 100% of the active ingredient in about 30 hours to about 80 hours.