Derivatized c60 molecules and methods and materials for using derivatized c60 molecules to reduce radiation injury
AssigneesMayo Foundation for Medical Education and Research, AGNI Medical LLC
InventorsSunil Krishnan, Yuri Mackeyev, Elena Vishnyakova
Life of this patent
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Abstract
This document provides derivatized C60 molecules (e.g., C60-serinol) and methods and materials for using derivatized C60 molecules (e.g., C60-serinol) to reduce radiation injury. For example, methods and materials for using derivatized C60 molecules (e.g., C60-serinol) to reduce, prevent, and/or mitigate radiation injury (e.g., radiation induced oxidative stress and/or DNA damage) to cells (e.g., human cells) or to a mammal (e.g., a human) during, for example, outer space missions are provided.
Claims28
A method for prolonging survival of a mammal exposed to a lethal level of radiation, wherein said method comprises administering a composition comprising C60-serinol to said mammal, wherein said mammal survives longer than if said mammal was not administered said composition.
4-8. (canceled)
A method for prolonging survival of a mammal expected to be exposed to a lethal level of radiation, wherein said method comprises administering a composition comprising C60-serinol to said mammal before said mammal is exposed to said lethal level of radiation, wherein said mammal survives longer than if said mammal was not administered said composition.
12-16. (canceled)
A method for reducing the severity of radiation-induced injury, wherein said method comprises administering a composition comprising C60-serinol to a mammal exposed to a damaging level of radiation, wherein the severity of radiation-induced injury of said mammal is less than the severity of radiation-induced injury if said mammal was not administered said composition.
20-24. (canceled)
A method for reducing the severity of radiation-induced injury, wherein said method comprises administering a composition comprising C60-serinol to a mammal prior to exposure to a damaging level of radiation, wherein said mammal is exposed to said damaging level of radiation, and wherein the severity of radiation-induced injury of said mammal is less than the severity of radiation-induced injury if said mammal was not administered said composition.
28-32. (canceled)
A method for treating a mammal to reduce the number of reactive oxygen species in said mammal following radiation exposure, wherein said method comprises administering a composition comprising C60-serinol to said mammal before, during, or after exposure to a damaging level of radiation, wherein said mammal is exposed to said damaging level of radiation, and wherein the number of reactive oxygen species in said mammal following said radiation exposure is less than the number of reactive oxygen species in said mammal if said mammal was not administered said composition.
36-43. (canceled)
A composition comprising C60-serinol.
(canceled)
A method of making C60-serinol, wherein said method comprises:
- (a) reacting serinol malonate tetraacetate with [60]fullerene in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene and perbromomethane in toluene to yield C60-serinol acetate;
- and
- (b) reacting said C60-serinol acetate with hydrochloric acid in an aqueous solution of dioxane to yield C60-serinol.
(canceled)
(canceled)
Dependencies are inferred from the claim text.