Process for continuous hot melt granulation of low soluble pharmaceuticals

A process of loading a polymer with an active pharmaceutical ingredient in a melt granulation process comprising the steps of:

• a) kneading a mixture comprising at least one active pharmaceutical ingredient and polyvinyl alcohol in a heated screw barrel of an extruder wherein the temperature in at least one zone along the length of the screw barrel is above the melting temperature of the at least one active pharmaceutical ingredient and below the decomposition temperature of the polyvinyl alcohol to form a kneaded mixture and
• b) transporting the kneaded mixture through an outlet.