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AssigneeWatershed Medical, Inc.
InventorsChristopher R. KINSELLA, Jr., Saniya ALI, Clay Justin NOLAN, Rush Lloyd BARTLETT, II
Estimating the term…
The invention provides a formulation and method for the treatment of urinary system disorders, wherein the formulation comprises a controlled release drug delivery system for intravesicular administration to a patient. Controlled release microparticles in the formulation are comprised of a pharmacologically active agent and a controlled release carrier, where the microparticles are buoyant in urine. Microparticle buoyancy in urine ensures that the formulation continues to release the active agent into a patient's bladder throughout the duration of an extended drug delivery time period. Methods of treating urinary system disorders by intravesicular administration of the microparticle formulation to a subject are also provided, and include methods of treating urinary system infections, bladder cancer, incontinence, and other urinary system disorders.
A controlled release pharmaceutical formulation for intravesical administration to a subject, the formulation comprising a population of microparticles having a mean diameter of 500 nm to 2000 μm and comprised of 2.5 wt. % to 95 wt. % of a pharmacologically active agent and 5 wt. % to 97.5 wt. % of a controlled release carrier,
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The formulation of claim 4, wherein the carrier provides for controlled release of the pharmacologically active agent in the urinary system and/or bladder.
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A method of treating a urinary system disorder in a subject, the method comprising intravesical administration of a formulation comprised of microparticles having a mean diameter of 50 nm to 2000 μm, 2.5 wt. % to 95 wt. % of a pharmacologically active agent, and 5 wt. % to 97.5 wt. % of a controlled release carrier,
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Dependencies are inferred from the claim text.