Cationic lipids and uses thereof

Abstract

Disclosed herein is directed to cationic lipids and lipid nanoparticles (LNPs) comprising the same for encapsulating and delivering active pharmaceutical ingredients (API) (e.g., nucleic acids) into cells. The cationic lipid has the structure of formula (I), wherein, at least one of X and Y is —(C═O)CH2NH2, and the other X, Y, and Z are independently selected from the group consisting of —(C═O)CH2NH2, —[C═O)CH2NH](C═O)R1, —(C═O)R1, and H, wherein R1 is C9-25 alkyl, or C13-21 alkenyl. Also encompasses herein is a method of treating a disease in a subject in need thereof, comprising administering an effective amount of the LNPs set forth above to the subject.

Dependencies are inferred from the claim text.