Implantable devices for drug delivery with reduced burst release
AssigneeFedson, Inc.
InventorsRajesh A. PATEL, Sunil SREEDHARAN, Sunil R. BHONSLE
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Abstract
The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.
Claims65
An implantable device for delivery of a pharmaceutical substance comprising:
- a core comprising a first polymeric material and a core pharmaceutical substance;
- and
- a shell comprising ethylene vinyl acetate and a porogen material;
- wherein the porogen material comprises particles with a mean diameter between 1 micrometer and 300 micrometers;
- wherein the implantable device has reduced burst release as compared to a comparison device made entirely of the first polymeric material and the core pharmaceutical substance.
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A method of forming an implantable device comprising:
- extruding a first composition to form a core, the first composition comprising a first polymeric material and a core pharmaceutical substance;
- and
- coating the core with a second composition to form a shell, the second composition comprising ethylene vinyl acetate and a porogen material, wherein the porogen material comprises particles with a mean diameter between 1 micrometer and 300 micrometers.
A method of forming an implantable device comprising:
- co-extruding a first composition and a second composition, where the first composition is extruded to form a core, the first composition comprising a first polymeric material and a core pharmaceutical substance;
- and the co-extruded second composition forming a shell around the core, the second composition comprising ethylene vinyl acetate and a porogen material, wherein the porogen material comprises particles with a mean diameter between 1 micrometer and 300 micrometers.
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Dependencies are inferred from the claim text.