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AssigneesThe European Syndicate of Synthetic Scientists and Industrialists, Commissariat A L' Energie Atomique Et Aux Energies Alternatives
InventorsPierre-Yves Vincent BOURGUIGNON, Philippe MARLIÈRE, Valérie PEZO, Raphael MEHEUST
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Described is a novel family of DNA polymerases identified in bacteriophages (mainly from the family of Siphiroviridae) which are able to accept 2-amino-2′-deoxyadenosine 5′-triphosphate (dZTP) as a substrate but which do not accept deoxyadenosine 5′-triphosphate (dATP) as a substrate. Also described are recombinant nucleic acid molecules, encoding such polymerases, vectors comprising such nucleic acid molecules, host cells transformed with such nucleic acid molecules or vectors as well as to methods for producing DNA molecules containing 2-amino-2′-deoxyadenosine (dZ) instead of 2′-deoxyadenosine (dA) by making use of a novel polymerase.
A method for the production of a DNA molecule comprising 2-amino-2′-deoxyadenosine (dZ) instead of deoxyadenosine (dA) comprising the steps of:
A recombinant nucleic acid molecule comprising a nucleotide sequence encoding a polymerase wherein the polymerase is characterized by the following features:
A polymerase encoded by the nucleic acid molecule of 10.
Dependencies are inferred from the claim text.