4-aminoquinolines for treatment of multidrug resistant malaria

A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 is selected from H and halogen;
• R2 is selected from H, halogen, and halomethyl;
• R3 is selected from H, C1-C7 straight or branched alkyl, —C(═O)—C1-C7 straight or branched alkyl, —C(═O)—NH—C1-C7 straight or branched alkyl, C3-C10 cycloalkyl, —CH2—C3-C10 cycloalkyl, —C(═O)—C3-C10 cycloalkyl, —C(═O)—NH—C3-C10 cycloalkyl, and benzyl;
• and
• X is selected from N and C;
• with the proviso that, when R1 is H, R2 is not H;
• with the proviso that, when R2 is H, R1 is not H;
• and
• with the proviso that the compound is not N-(4-(4-benzylpiperazin-1-yl)phenyl)-7-chloroquinolin-4-amine;
• N-(4-(4-butylpiperazin-1-yl)phenyl)-7-chloroquinolin-4-amine;
• 7-chloro-N-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-4-amine;
• 7-chloro-N-(4-(1-methylpiperidin-4-yl)phenyl)quinolin-4-amine;
• 6-bromo-N-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-4-amine;
• or 6-bromo-N-(4-(4-ethylpiperazin-1-yl)phenyl)quinolin-4-amine;
• or a pharmaceutically acceptable salt thereof.