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US 2024/0181455 A1Published application
Hydro-cyclone centrifuge apheretic system
AssigneeAstrin Biosciences, Inc.
InventorsJiarong HONG, Mahdi AHMADI, Kaylee SMITH, Jayant PARTHASARATHY
Life of this patent
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Abstract
The present embodiments relate to an apheretic system incorporating one or more centrifuge devices. A biological fluid containing cells (or another fluid) can be obtained and directed to a centrifuge device to separate particles by a particle size and/or a flow rate. The centrifuge device can include a center-axis centrifuge, an off-center centrifuge, and/or a hydro-cyclone centrifuge device. The separated particles can be directed/drawn into either an outlet to a return or into a collection container for further testing.
Claims20
A hydro-cyclone apheretic system comprising:
- an inlet configured to obtain a biological fluid containing cells from a patient;
- a first hydro-cyclone centrifuge device connected to the inlet, the first hydro-cyclone centrifuge device comprising:
- at least one intake to obtain at least a portion of the biological fluid containing cells at a cylindrical portion of the first hydro-cyclone centrifuge device;
- an overflow disposed at a top portion of the cylindrical portion, wherein a first portion of the biological fluid containing cells are configured to be separated in the first hydro-cyclone centrifuge device and output at the overflow;
- and
- an underflow disposed at a bottom portion of a conical portion of the first hydro-cyclone centrifuge device, wherein a second portion of the biological fluid containing cells are configured to be separated in the first hydro-cyclone centrifuge device and output at the underflow;
- an outlet connected to the overflow, wherein the first portion of the biological fluid containing cells are configured to be output from the overflow to the outlet and returned to the patient via a return line;
- and
- a first collection container connected to the underflow, wherein the second portion of the biological fluid containing cells are configured to be output from the underflow to the first collection container.
6 more elements
A method comprising:
- obtaining, at an inlet, a biological fluid containing cells from a patient;
- directing the biological fluid containing cells from the inlet to at least one intake of a first hydro-cyclone centrifuge device, wherein the first hydro-cyclone centrifuge device is configured to cause separation of the biological fluid containing cells;
- directing a first portion of the biological fluid containing cells separated in the first hydro-cyclone centrifuge device to an overflow disposed at a top portion of the first hydro-cyclone centrifuge device;
- directing a second portion of the biological fluid containing cells separated in the first hydro-cyclone centrifuge device to an underflow disposed at a bottom portion of the first hydro-cyclone centrifuge device;
- outputting the first portion of the biological fluid containing cells from the overflow to an outlet configured to return the first portion of the biological fluid containing cells to the patient;
- and
- outputting the second portion of the biological fluid containing cells from the underflow to a first collection container.
4 more elements
A system comprising:
- an inlet configured to obtain a biological fluid containing cells;
- a series of interconnected hydro-cyclone centrifuge devices comprising:
- a first hydro-cyclone centrifuge device connected to the inlet, wherein the first hydro-cyclone centrifuge device includes:
- at least one intake connected to the inlet;
- an overflow configured to output a first portion of the biological fluid containing cells separated in the first hydro-cyclone centrifuge device;
- and
- an underflow configured to output a second portion of the biological fluid containing cells separated in the first hydro-cyclone centrifuge device;
- a second hydro-cyclone centrifuge device with at least one intake connected to the underflow of the first hydro-cyclone centrifuge device, the second hydro-cyclone centrifuge device configured to further separate the second portion of the biological fluid containing cells, with a first part being directed to an overflow of the second hydro-cyclone centrifuge device, and a second part being directed to an underflow of the second hydro-cyclone centrifuge device;
- and
- a third hydro-cyclone centrifuge device with at least one intake connected to the underflow of the second hydro-cyclone centrifuge device, the third hydro-cyclone centrifuge device configured to further separate the second part of the biological fluid containing cells, with a first part being directed to an overflow of the third hydro-cyclone centrifuge device, and a second part being directed to an underflow of the third hydro-cyclone centrifuge device;
- an outlet connected to the overflow of each of the series of hydro-cyclone centrifuge devices;
- and
- a first collection container connected to the underflow of the third hydro-cyclone centrifuge device.
10 more elements
Dependencies are inferred from the claim text.