Biochemical activation of dysfunctional skeletal stem cells for skeletal regeneration

Abstract

Aged skeletal stem cells are targeted for reactivation by administration of a combination of a bone morphogenetic protein (BMP) and an inhibitor of CSF1, which combination of factors may be topically administered to a targeted skeletal site. In some embodiments the topical administration comprises placement of an implant, e.g. a matrix, gel, scaffold, etc. for localized delivery of the factor at the targeted skeletal site.

Dependencies are inferred from the claim text.