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AssigneesMassachusetts Institute ofTechnology, Tokitae LLC
InventorsAna Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
Estimating the term…
Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
-20. (canceled)
A microdevice for delivering a therapeutic or prophylactic agent to a human or animal, the microdevice comprising:
A method for delivering a therapeutic, prophylactic, nutraceutical, or diagnostic agent to an individual in need thereof, the method comprising administering to the individual
A method of making a polymeric device comprising a polymeric shell and a core, wherein the core comprises at least one discrete region comprising an agent to be delivered, the method comprising:
Dependencies are inferred from the claim text.