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US 2024/0180983 A1Published application
Adenovirus encoding il-15
OwnerBrian Robert CHAMPION, Manuela ZONCAinventors
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Abstract
A group B adenovirus comprising a sequence of formula 5′ITR—B1-BA-B2-BX-BB-BY-B3-3′ITR, wherein: BY comprises a sequence -G1-G2n-G3m-G4p-G5q. G1 is a first transgene. G2 is a second transgene. G3 is a third transgene. G4 is a fourth transgene. G5 is a fifth transgene and IL-15 is encoded as a transgene in at least one of said locations, and characterised in that BY also encodes a polypeptide comprising the sushi domain of IL-15R alpha.
Claims18
1-29. (canceled)
A group B adenovirus comprising a sequence of formula (I):
- 5′ITR-B1-BA-B2-BX-BB-BY-B3-3′ITR (I)
- wherein:
- B1 is a bond or comprises:
- E1A, E1 B or E1A-E1 B;
- BA comprises-E2B-L1-L2-L3-E2A-L4;
- B2 is a bond or comprises:
- E3;
- BX is a bond or a DNA sequence comprising:
- a restriction site, one or more transgenes or both;
- BB comprises L5;
- BY comprises a sequence -G1-G2n-G3m-G4p-G5q,
- wherein:
- G1 is a first transgene;
- G2 is a second transgene;
- G3 is a third transgene;
- G4 is a fourth transgene;
- G5 is a fifth transgene,
- B3 is a bond or comprises:
- E4;
- n is 0 or 1;
- m is 0 or 1;
- p is 0 or 1;
- q is 1;
- B3 is a bond or comprises:
- E4;
- wherein:
- IL-15 is encoded as a transgene in position G5,
- characterised in that BY also encodes a polypeptide comprising the sushi domain of IL-15R alpha, and does not comprise a transmembrane or GPI anchor such that it is not membrane anchored when expressed.
25 more elements
Dependencies are inferred from the claim text.