Targeting junctional epithelium in the gingival crevice for immune modulation

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A method of triggering an immune response in a subject comprising:

• providing an effective amount of one or more antigens, immunogens, allergens, or combinations thereof into a gingival crevice, wherein the amount is sufficient to trigger an immune response to the antigen;
• wherein the one or more antigens, immunogens, allergens, or combinations thereof are embedded, coated, or attached to a delivery device that targets a junctional epithelium at a gingival crevice.

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An immunization comprising an effective amount of one or more antigens, immunogens, allergens, or combinations thereof on a delivery device that targets a junctional epithelium at a gingival crevice, wherein an amount of the one or more antigens, immunogens, allergens, or combinations thereof is sufficient to activate or modulate an immune response.

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A method of making a floss that comprises a pre-determined amount of one or more active agents comprising:

• providing a floss;
• and
• depositing on the floss one or more deposits of the active agent in a pharmacologically acceptable carrier, wherein each deposit has a known, pre-determined amount of the active agent.

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A floss that comprises a pre-determined amount of one or more active agents comprising:

• a floss;
• and
• a deposit on the floss one or more depots of the active agent in a pharmacologically acceptable carrier, wherein each droplet or patch has a known, pre-determined amount of the active agent.

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