Particle compositions comprising polysarcosine lipid conjugates
AssigneeCalusa Bio, LLC
InventorsBradford T. Sullivan, Kevin N. Sill
Life of this patent
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Abstract
The present disclosure features particle compositions, such as liposomes and lipid nanoparticles, comprising a polysarcosine-lipid conjugate, as well as methods of making and using the same.
Claims43
A particle comprising:
- (i) a polymer of Formula (I-d):
- or a pharmaceutically acceptable salt thereof, wherein each of R6, R7, and R8 is independently hydrogen, heteroalkyl, alkyl, alkenyl, or alkynyl;
- each of R9a, R9b, R10a, and R10b is independently hydrogen, alkyl, or halo;
- each of x and y is independently an integer between 1 and 20;
- and z is an integer between 5 and 90;
- and one or more of:
- (ii) a phospholipid;
- (iii) a steroid;
- (iv) a payload;
- and
- (v) an additional lipid component.
The particle of any one of the preceding claims, wherein z is 5-50.
A lipid nanoparticle comprising:
- (i) a polymer of Formula (I-d):
- or a pharmaceutically acceptable salt thereof, wherein each of R6, R7, and R8 is independently hydrogen, heteroalkyl, alkyl, alkenyl, or alkynyl;
- each of R9a, R9b, R10a, and R10b is independently hydrogen, alkyl, or halo;
- each of x and y is independently an integer between 1 and 20;
- and z is an integer between 5 and 90;
- and one or more of:
- (ii) a phospholipid;
- (iii) a steroid;
- (iv) a payload;
- and
- (v) an additional lipid component.
A lipid nanoparticle comprising:
- (i) a polymer of Formula (I-d):
- or a pharmaceutically acceptable salt thereof, wherein each of R6, R7, and R8 is independently hydrogen, heteroalkyl, alkyl, alkenyl, or alkynyl;
- each of R9a, R9b, R10a, and R10b is independently hydrogen, alkyl, or halo;
- each of x and y is independently an integer between 1 and 20;
- and z is an integer between 5 and 90:
- (ii) a phospholipid;
- (iii) a steroid;
- (iv) a payload;
- and
- (v) an additional lipid component.
A lipid nanoparticle comprising:
- (i) a polymer having the structure:
- or a pharmaceutically acceptable salt thereof,
- and one or more of:
- (ii) a phospholipid;
- (iii) a steroid;
- (iv) a payload;
- and
- (v) an additional lipid component.
A lipid nanoparticle comprising:
- (i) a polymer having the structure:
- or a pharmaceutically acceptable salt thereof,
- (ii) a phospholipid;
- (iii) a steroid;
- (iv) a payload;
- and
- (v) an additional lipid component.
A lipid nanoparticle comprising:
- (i) a polymer having the structure:
- or a pharmaceutically acceptable salt thereof,
- (ii) a phospholipid;
- (iii) a steroid;
- (iv) a payload;
- and
- (v) an additional lipid component.
A method of delivering a payload to a subject or cell, the method comprising administering to the subject or cell a particle comprising:
- (i) a polymer of Formula (I-d):
- or a pharmaceutically acceptable salt thereof, wherein each of R6, R7, and R8 is independently hydrogen, heteroalkyl, alkyl, alkenyl, or alkynyl;
- each of R9a, R9b, R10a, and R10b is independently hydrogen, alkyl, or halo;
- each of x and y is independently an integer between 1 and 20;
- and z is an integer between 5 and 90;
- and one or more of:
- (ii) a phospholipid;
- (iii) a steroid;
- (iv) a payload;
- and
- (v) an additional lipid component.
A method of treating a disease, disorder, or condition in a subject, the method comprising administering to the subject a particle comprising:
- (i) a polymer of Formula (I-d):
- or a pharmaceutically acceptable salt thereof, wherein each of R6, R7, and R8 is independently hydrogen, heteroalkyl, alkyl, alkenyl, or alkynyl;
- each of R9a, R9b, R10a, and R10b is independently hydrogen, alkyl, or halo;
- each of x and y is independently an integer between 1 and 20;
- and z is an integer between 5 and 90;
- and one or more of:
- (ii) a phospholipid;
- (iii) a steroid;
- (iv) a payload;
- and
- (v) an additional lipid component.
Dependencies are inferred from the claim text.